Disease-specific, or all-cause mortality as an endpoint?

How valid is the use of all-cause mortality in randomized screening trials?

In the light of overdiagnosis, overtreatment and resultant deaths, should all-cause mortality be the end point in randomized screening trials?

This paper examines the validity of disease-specific deaths as an endpoint in randomized cancer screening trials.

‘Because all-cause mortality is not affected by bias in classifying the cause of death, it should be examined when interpreting the results of randomized cancer-screening trials.’
All-Cause Mortality in Randomized Trials of Cancer Screening. William C Black, David A Haggstrom and H Gilbert Welch. Journal of the National Cancer Institute Vol 94, issue 3. Pp 167-173.
http://jnci.oxfordjournals.org/content/94/3/167.full

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About bmitzi

Medical writer, author, artist. Cancer campaigner. Aiming always to improve health services and bring compassion into health care.
This entry was posted in breast screening, Campaigns, cancer, clinical trials, Compassion in healthcare, death, guidelines, healthcare modernisation, information, Screening Mammography, speaking out, Uncategorized and tagged , , . Bookmark the permalink.

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