Surgical wounding associated with the extirpation of experimental primary cancers can trigger angiogenesis in previously dormant micrometastatic tumour deposits, which can result in the acceleration ofrelapse and death….’ ‘The uniform incapacity of randomised controlled studies of screening mammography to show early surgical advantage of screened populations aged 40–49 years might relate to this biology..
The lack of mammographic benefit…’ (in the Canandian study) …’can be explained by the extra 550 biopsies done in year 1 in the intervention group if 14 of these biopsies showed false-negative results and caused lymphangiogenesis and stage progression…’
‘…Our hypothesis is that stage progression associated with excessive biopsies in young women with abnormal mammograms offsets any long-term benefit for the screened populations. Michael Retsky, Romano Demicheli, William Hrushesky. The Lancet, Correspondence: Vol 357; 1048 (March 31, 2001).