Excerpt from authors’ conclusion:
Our experimental findings demonstrate for the first time that in the setting of malignant breast cancer, performance of a CNB is associated with a significantly increased incidence of pulmonary metastases. We also show that an additional impact of CNB includes creation of a distinctly immunosuppressive and pro-metastatic tumor microenvironment with elevated TGF-β/SOX-4–associated EMT and significantly higher CTC levels. In this era of digital mammography when smaller breast cancers are being detected, presumably in a pre-metastatic state, biologic knowledge of the potential harms associated with the traditional work-up of breast cancer through the application of a CNB needs to be considered…’ Edward Gitau Mathenge, Cheryl Ann Dean, Derek Clements et al. Neoplasia, Vol 16, No 11, pp950-960.
‘Circulating tumour cells increased immediately after the taking of biopsies from human squamous cell, prostate, breast and hepatocellular carcinomas. Although no increased risk of biopsy-induced distant metastasis has been reported for any type of tumour, this is inconclusive due to a lack of non-biopsied control groups in human studies. Reports of biopsy-induced metastasis in animal tumours indicate that the taking of transcutaneous biopsies from urogenital tumours may be associated with a risk of NTM. However, there is no evidence of a general increase in risk of distant metastases in any tumour type in people or animals. The overall risk therefore appears to be negligible when compared to the valuable information obtained from biopsies in veterinary practice.’ – ‘Does the taking of biopsies affect the metastatic potential of tumours? A systematic review of reports on veterinary and human cases and animal models’ – Klopfleisch R, Sperling C, Kershaw O, Gruber AD. Vet J. 2011 Nov, 190(2):e31-42